2025
Salazar, C. A. S.; Sole-Barber, D.; Wan, S. S.; Rasch, J. K.; Reitz, M.; Cullinane, B.; Asgari, N.; Needham, L. M.; Yuen-Zhou, J.; Goldsmith, R. H., The Origin of Single-Molecule Sensitivity in Label-Free Solution-Phase Optical Microcavity Detection. ACS Nano 2025. 10.1021/acsnano.4c16276
Parrish, K.; Salij, A.; Kamp, K.; Smith, E.; Utama, M.; Bergsten, A.; Czerwinski, R.; Smith, M.; Hersam, M.; Poeppelmeier, K.; Goldsmith, R.; Tempelaar, R., Differential absorption of circularly polarized light by a centrosymmetric crystal. Science 2025, 388 (6752), 1194-1197. 10.1126/science.adr5478
Cullinane, B.; Ishii, K.; Kaur, S.; Tahara, T.; Goldsmith, R. H., Evidence of a Three-State Mechanism in DNA Hairpin Folding. Journal of the American Chemical Society 2025. 10.1021/jacs.4c17471
Cavell, A.; Jensen, E.; Brewster, B.; Wu, M.; Smith, M.; Mattei, M.; Czerwinski, R.; Kneeley, L.; Foy, M.; Fleming, A.; Harrison, E.; Peczonczyk, S.; Masias, A.; Goldsmith, R., Imaging of Lithium Ion Release from Individual Cathode Particles Shows Evidence for Diversity of Intraparticle Contacts. Chemistry of Materials 2025. 10.1021/acs.chemmater.5c00906
2024
Foote, A. K.; Ishii, K.; Cullinane, B.; Tahara, T.; Goldsmith, R. H., Quantifying Microsecond Solution-Phase Conformational Dynamics of a DNA Hairpin at the Single-Molecule Level. ACS Physical Chemistry Au 2024. 10.1021/acsphyschemau.3c00066
Needham, L.-M.; Saavedra, C.; Rasch, J. K.; Sole-Barber, D.; Schweitzer, B. S.; Fairhall, A. J.; Vollbrecht, C. H.; Wan, S.; Podorova, Y.; Bergsten, A. J.; Mehlenbacher, B.; Zhang, Z.; Tenbrake, L.; Saimi, J.; Kneely, L. C.; Kirkwood, J. S.; Pfeifer, H.; Chapman, E. R.; Goldsmith, R. H. Label-Free Detection and Profiling of Individual Solution-Phase Molecules. Nature 2024. 10.1038/s41586-024-07370-8
Chen, T. L.; Salij, A.; Parrish, K. A.; Rasch, J. K.; Zinna, F.; Brown, P. J.; Pescitelli, G.; Urraci, F.; Aronica, L. A.; Dhavamani, A.; Arnold, M. S.; Wasielewski, M. R.; di Bari, L.; Tempelaar, R.; Goldsmith, R. H. A 2D Chiral Microcavity Based on Apparent Circular Dichroism. Nat Commun 2024, 15 (1). 10.1038/s41467-024-47411-4
2023
Krasecki, V. K.; Sharma, A.; Cavell, A. C.; Forman, C.; Guo, S. Y.; Jensen, E. T.; Smith, M. A.; Czerwinski, R.; Friederich, P.; Hickman, R. J.; Gianneschi, N.; Aspuru-Guzik, A.; Cronin, L.; Goldsmith, R. H. The Role of Experimental Noise in a Hybrid Classical-Molecular Computer to Solve Combinatorial Optimization Problems. ACS Cent Sci 2023, 9 (7), 1453–1465. 10.1021/acscentsci.3c00515
White, D. S.; Smith, M. A.; Chanda, B.; Goldsmith, R. H. Strategies for Overcoming the Single-Molecule Concentration Barrier. ACS Measurement Science Au 2023, 3, 239–257. 10.1021/acsmeasuresciau.3c00002
2022
Pan, F.; Karlsson, K.; Nixon, A. G.; Hogan, L. T.; Ward, J. M.; Smith, K. C.; Masiello, D. J.; Nic Chormaic, S.; Goldsmith, R. H. Active Control of Plasmonic-Photonic Interactions in a Microbubble Cavity. Journal of Physical Chemistry C 2022, 126 (48), 20470–20479. 10.1021/acs.jpcc.2c05733
Mattei, M. S.; Liu, B.; Mazzei Capote, G. A.; Liu, Z.; Hacha, B. G.; Osswald, T.; Yu, Z.; Goldsmith, R. H. Three-Dimensional Printed Planar Polymer Photonic Topological Insulator Waveguides and Their Robustness to Lattice Defects. ACS Photonics 2022, 9 (5), 1793–1802. 10.1021/acsphotonics.2c00332
2021
White, D. S.; Chowdhury, S.; Idikuda, V.; Zhang, R.; Retterer, S. T.; Goldsmith, R. H.; Chanda, B. CAMP Binding to Closed Pacemaker Ion Channels Is Non-Cooperative. Nature 2021, 595 (7868), 606–610. 10.1038/s41586-021-03686-x
2020
Cavell, A. C.; Krasecki, V. K.; Li, G.; Sharma, A.; Sun, H.; Thompson, M. P.; Forman, C. J.; Guo, S. Y.; Hickman, R. J.; Parrish, K. A.; Aspuru-Guzik, A.; Cronin, L.; Gianneschi, N. C.; Goldsmith, R. H. Optical Monitoring of Polymerizations in Droplets with High Temporal Dynamic Range. Chem Sci 2020, 11 (10), 2647–2656. 10.1039/c9sc05559b
Pan, F.; Smith, K. C.; Nguyen, H. L.; Knapper, K. A.; Masiello, D. J.; Goldsmith, R. H. Elucidating Energy Pathways through Simultaneous Measurement of Absorption and Transmission in a Coupled Plasmonic-Photonic Cavity. Nano Lett 2020, 20 (1), 50–58. 10.1021/acs.nanolett.9b02796
2019
Ying, L.; Zhou, M.; Mattei, M.; Liu, B.; Campagnola, P.; Goldsmith, R. H.; Yu, Z. Extended Range of Dipole-Dipole Interactions in Periodically Structured Photonic Media. Phys Rev Lett 2019, 123 (17). 10.1103/PhysRevLett.123.173901
Rea, M. T.; Pan, F.; Horak, E. H.; Knapper, K. A.; Nguyen, H. L.; Vollbrecht, C. H.; Goldsmith, R. H. Investigating the Mechanism of Post-Treatment on PEDOT/PSS via Single-Particle Absorption Spectroscopy. Journal of Physical Chemistry C 2019, 123 (51), 30781–30790. 10.1021/acs.jpcc.9b06259
Hogan, L. T.; Horak, E. H.; Ward, J. M.; Knapper, K. A.; Nic Chormaic, S.; Goldsmith, R. H. Toward Real-Time Monitoring and Control of Single Nanoparticle Properties with a Microbubble Resonator Spectrometer. ACS Nano 2019, 13 (11), 12743–12757. 10.1021/acsnano.9b04702
Foote, A. K.; Manger, L. H.; Holden, M. R.; Margittai, M.; Goldsmith, R. H. Time-Resolved Multirotational Dynamics of Single Solution-Phase Tau Proteins Reveals Details of Conformational Variation. Physical Chemistry Chemical Physics 2019, 21 (4), 1863–1871. 10.1039/c8cp06971a
2018
Horak, E. H.; Rea, M. T.; Heylman, K. D.; Gelbwaser-Klimovsky, D.; Saikin, S. K.; Thompson, B. J.; Kohler, D. D.; Knapper, K. A.; Wei, W.; Pan, F.; Gopalan, P.; Wright, J. C.; Aspuru-Guzik, A.; Goldsmith, R. H. Exploring Electronic Structure and Order in Polymers via Single-Particle Microresonator Spectroscopy. Nano Lett 2018, 18 (3), 1600–1607. 10.1021/acs.nanolett.7b04211
Hinton, D. A.; Ng, J. D.; Sun, J.; Lee, S.; Saikin, S. K.; Logsdon, J.; White, D. S.; Marquard, A. N.; Cavell, A. C.; Krasecki, V. K.; Knapper, K. A.; Lupo, K. M.; Wasielewski, M. R.; Aspuru-Guzik, A.; Biteen, J. S.; Gopalan, P.; Goldsmith, R. H. Mapping Forbidden Emission to Structure in Self-Assembled Organic Nanoparticles. J Am Chem Soc 2018, 140 (46), 15827–15841. 10.1021/jacs.8b09149
2017
Thakkar, N.; Rea, M. T.; Smith, K. C.; Heylman, K. D.; Quillin, S. C.; Knapper, K. A.; Horak, E. H.; Masiello, D. J.; Goldsmith, R. H. Sculpting Fano Resonances to Control Photonic-Plasmonic Hybridization. Nano Lett 2017, 17 (11), 6927–6934. 10.1021/acs.nanolett.7b03332
Padilla, N. A.; Rea, M. T.; Foy, M.; Upadhyay, S. P.; Desrochers, K. A.; Derus, T.; Knapper, K. A.; Hunter, N. H.; Wood, S.; Hinton, D. A.; Cavell, A. C.; Masias, A. G.; Goldsmith, R. H. Tracking Lithium Ions via Widefield Fluorescence Microscopy for Battery Diagnostics. ACS Sens 2017, 2 (7), 903–908. 10.1021/acssensors.7b00087
Manger, L. H.; Rowley, M. B.; Fu, Y.; Foote, A. K.; Rea, M. T.; Wood, S. L.; Jin, S.; Wright, J. C.; Goldsmith, R. H. Global Analysis of Perovskite Photophysics Reveals Importance of Geminate Pathways. Journal of Physical Chemistry C 2017, 121 (2), 1062–1071. 10.1021/acs.jpcc.6b11547
Manger, L. H.; Foote, A. K.; Wood, S. L.; Holden, M. R.; Heylman, K. D.; Margittai, M.; Goldsmith, R. H. Revealing Conformational Variants of Solution‐Phase Intrinsically Disordered Tau Protein at the Single‐Molecule Level. Angewandte Chemie 2017, 129 (49), 15790–15794. 10.1002/ange.201708242
Goldschen‐Ohm, M. P.; White, D. S.; Klenchin, V. A.; Chanda, B.; Goldsmith, R. H. Observing Single‐Molecule Dynamics at Millimolar Concentrations. Angewandte Chemie 2017, 129 (9), 2439–2442. 10.1002/ange.201612050
2016
Ng, J. D.; Upadhyay, S. P.; Marquard, A. N.; Lupo, K. M.; Hinton, D. A.; Padilla, N. A.; Bates, D. M.; Goldsmith, R. H. Single-Molecule Investigation of Initiation Dynamics of an Organometallic Catalyst. J Am Chem Soc 2016, 138 (11), 3876–3883. 10.1021/jacs.6b00357
Lupo, K. M.; Hinton, D. A.; Ng, J. D.; Padilla, N. A.; Goldsmith, R. H. Probing Heterogeneity and Bonding at Silica Surfaces through Single-Molecule Investigation of Base-Mediated Linkage Failure. Langmuir 2016, 32 (36), 9171–9179. 10.1021/acs.langmuir.6b02456
Knapper, K. A.; Heylman, K. D.; Horak, E. H.; Goldsmith, R. H. Chip-Scale Fabrication of High-Q All-Glass Toroidal Microresonators for Single-Particle Label-Free Imaging. Advanced Materials 2016, 28 (15), 2945–2950. 10.1002/adma.201504976
Heylman, K. D.; Thakkar, N.; Horak, E. H.; Quillin, S. C.; Cherqui, C.; Knapper, K. A.; Masiello, D. J.; Goldsmith, R. H. Optical Microresonators as Single-Particle Absorption Spectrometers. Nat Photonics 2016, 10 (12), 788–795. 10.1038/nphoton.2016.217
2013-2015
Heylman, K. D.; Knapper, K. A.; Goldsmith, R. H. Photothermal Microscopy of Nonluminescent Single Particles Enabled by Optical Microresonators. Journal of Physical Chemistry Letters 2014, 5 (11), 1917–1923. 10.1021/jz500781g